“Our results should reassure the public about the safety of antihypertensive drugs with respect to cancer, which is of paramount importance given their proven benefit for protecting against heart attacks and strokes,” mentioned research writer Emma Copland, an epidemiologist on the University of Oxford, UK.
A possible link between blood pressure medicine and most cancers has been debated for greater than 40 years. The proof for an elevated or decreased danger of most cancers with the usage of antihypertensive medication has been inconsistent and conflicting.
This was the biggest research on most cancers outcomes in contributors of randomised trials investigating antihypertensive medication – round 260,000 individuals in 31 trials. Investigators of all trials have been requested for info on which contributors developed most cancers.
Much of this info has not been revealed earlier than, making the present evaluation probably the most detailed but. Five antihypertensive drug courses have been investigated individually: angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), beta-blockers, calcium channel blockers (CCBs), and diuretics.
The investigators estimated the impact of every drug class on the danger of growing any sort of most cancers, of dying from most cancers, and of growing breast, colorectal, lung, prostate and pores and skin cancers.
They additionally examined whether or not there have been any variations based on age, gender, physique dimension, smoking standing, and earlier antihypertensive medication use earlier than participating within the trial.
During a median of 4 years, there have been round 15,000 new diagnoses of most cancers. The researchers discovered no proof that the usage of any antihypertensive drug class elevated the danger of most cancers.
This discovering was constant no matter age, gender, physique dimension, smoking standing, and earlier antihypertensive medication use. Each drug class was in contrast in opposition to all different management teams, together with placebo, customary remedy, and different drug courses.
There was no necessary impact on any particular person drug class on general most cancers danger. The hazard ratio (HR) for any most cancers was 0.99 (95 % confidence interval [CI]) 0.94-1.04) with ACE inhibitors, 0.97 (95 % CI 0.93-1.02) with ARBs, 0.98 (95 % CI 0.89-1.08) with beta-blockers, 1.06 (95 % CI 1.01-1.11) with CCBs and 1.01 (95 % CI 0.95-1.07) with diuretics.
In statistical phrases, these impact sizes weren’t considerably completely different from one another, so there was no proof of an elevated danger of most cancers with any of the drug courses.
Similarly, there was no proof that any sort of antihypertensive medication had an impact on the likelihood of growing breast, colorectal, lung, prostate, or pores and skin most cancers.
When contributors have been adopted all through the course of every trial, there was no indication that the danger of most cancers elevated with longer period of use of those therapies.
“Our study has addressed an ongoing controversy about whether antihypertensive medication increases the risk of developing cancer. We used the largest individual-level randomised evidence on antihypertensive medication to date and provide evidence for the safety of blood pressure-lowering drugs in relation to cancer,” Copland mentioned.